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Related Experiment Video

Updated: Jan 6, 2026

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
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Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management

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Multifunctional Scaffold Biosensor and Drug Delivery System for Bacterial Infection Prevention During Skin Wound

Leonor Resina1,2, Pau Caballero1, Grant Guggenbiller3

  • 1IMEM-BRT Group, Departament d'Enginyeria Química, EEBE, Universitat Politècnica de Catalunya, Barcelona, Spain.

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|September 8, 2025
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Summary

This study presents a novel hydrogel system for advanced wound care, integrating carboxymethyl cellulose (CMC) and limonene (LIM) for enhanced healing, infection monitoring, and drug delivery. The system utilizes conductive polymers for real-time diagnostics and electrostimulated curcumin release.

Keywords:
biosensorconducting polymercontrolled drug releasehydrogelwound healing

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Nanotechnology

Background:

  • Advanced wound management requires integrated systems for healing, infection control, and monitoring.
  • Current treatments often lack multifunctionality, necessitating innovative material designs.

Purpose of the Study:

  • To develop a multifunctional hydrogel system for enhanced wound healing, infection prevention, and real-time monitoring.
  • To integrate carboxymethyl cellulose (CMC) hydrogel with a 3D-printed limonene (LIM) scaffold and conductive polymers (PEDOT:PSS, PEDOT:CUR).

Main Methods:

  • Fabrication of a CMC-CA hydrogel matrix with an embedded 3D-printed LIM scaffold.
  • Incorporation of poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) and curcumin-loaded PEDOT (PEDOT:CUR) nanoparticles.
  • Evaluation of mechanical properties, electrochemical detection of bacterial infection, and electrostimulated curcumin release.

Main Results:

  • The CMC-CA hydrogel exhibited suitable mechanical properties for wound applications.
  • The integrated system enabled real-time monitoring of bacterial growth and electrostimulated release of curcumin.
  • Curcumin demonstrated antibacterial activity against Escherichia coli and Staphylococcus aureus.
  • Electrostimulation promoted cell proliferation and accelerated wound healing.

Conclusions:

  • The CMC-CA/LIM/PEDOT system offers a promising multifunctional approach for wound management.
  • It addresses critical challenges by combining mechanical support, infection monitoring, and controlled drug delivery.
  • The system facilitates enhanced healing through electrical stimulation and targeted therapeutic release.