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Family History as a Dominant Risk Factor for Uninvestigated Dyspepsia and Chronic Constipation: A Rome IV-Based Study
Nhu Thi Hanh Vu1,2, Duc Trong Quach3, Mai Ngoc Luu3
1Department of Internal Medicine, School of Medicine - University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh, Vietnam, vuhanhnhu@ump.edu.vn.
Family history is a significant risk factor for uninvestigated dyspepsia (UD) and chronic constipation (CC) in young adults. These findings emphasize the importance of considering familial factors in prevention and intervention strategies.
Area of Science:
- Gastroenterology
- Gut-Brain Interaction Disorders
- Public Health
Background:
- Uninvestigated dyspepsia (UD) and chronic constipation (CC) are prevalent gut-brain interaction disorders.
- Limited research exists on risk factors in young adults, especially concerning family history.
Purpose of the Study:
- To investigate associated factors for UD and CC in Japanese university students.
- To specifically examine the influence of family history on these conditions.
Main Methods:
- Cross-sectional study at Hiroshima University.
- Diagnosis based on Rome IV criteria.
- Multivariate logistic regression analysis to identify associated factors.
Main Results:
- Prevalence of UD was 7.3% and CC was 13.7% among 5,386 participants.
- Family history strongly associated with UD (OR: 4.29) and CC (OR: 2.77).
- Shared factors included depression and physical inactivity; specific factors varied by condition.
Conclusions:
- Family history is a predominant risk factor for both UD and CC in young adults.
- The association is stronger for UD than CC.
- Highlights the need to incorporate familial factors into prevention and intervention strategies.
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