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Related Concept Videos

Strong Acid and Base Solutions03:22

Strong Acid and Base Solutions

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A strong acid is a compound that dissociates completely in an aqueous solution and produces a concentration of hydronium ions equal to the initial concentration of acid. For example, 0.20 M hydrobromic acid will dissociate completely in water and produces 0.20 M of hydronium ions and 0.20 M of bromide ions.
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Weak Base Solutions03:21

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Some compounds produce hydroxide ions when dissolved by chemically reacting with water molecules. In all cases, these compounds react only partially and so are classified as weak bases. These types of compounds are also abundant in nature and important commodities in various technologies. For example, global production of the weak base ammonia is typically well over 100 metric tons annually, being widely used as an agricultural fertilizer, a raw material for chemical synthesis of other...
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The pH of a solution containing an acid can be determined using its acid dissociation constant and its initial concentration. If a solution contains two different acids, then its pH can be determined using one of several methods depending upon the relative strength of the acids and their dissociation constants.
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Extraction: Effects of pH00:53

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Consider a neutral form of an amine, B, with a partition coefficient, K, in a liquid mixture containing organic and aqueous phases. The pH of the aqueous phase affects the charge on acidic and basic solutes, and the charged form is usually more soluble in the aqueous phase. Suppose the conjugate acid form of the amine is soluble only in the aqueous phase while the base form is soluble in both phases. Then the distribution coefficient, D, can be given as the ratio of amine concentration in the...
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Complexation Equilibria: Factors Influencing Stability of Complexes01:09

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In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
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Mixtures of Acids01:19

Mixtures of Acids

1.3K
The pH of a solution containing an acid can be determined using its acid dissociation constant and initial concentration. If a solution contains two different acids, then its pH can be determined using one of several methods depending on the relative strength of the acids and their dissociation constants.
In a strong and weak acid mixture, the strong acid dissociates completely and becomes a source of almost all the hydronium ions present in the solution. In contrast, the weak acid shows...
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Kinetic Locking of pH-Sensitive Complexes for Mechanically Responsive Polymer Networks.

Stephen J K O'Neill1, Yuen Cheong Tse1, Zehuan Huang1

  • 1Melville Laboratory for Polymer Synthesis, Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.

Journal of the American Chemical Society
|September 8, 2025
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Summary
This summary is machine-generated.

This study introduces pH-responsive polymer networks using host-guest complexes for autonomous drug delivery. These materials show tunable mechanical properties and controlled cargo release at physiological pH.

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Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Biomedical Engineering

Background:

  • Developing autonomous drug delivery systems requires materials responsive to physiological pH changes.
  • Tumor microenvironments and inflamed joints exhibit pH variations (4.5-7.5) suitable for targeted therapies.

Purpose of the Study:

  • To engineer pH-responsive molecular interactions for dynamic polymer networks.
  • To create materials with tunable mechanical and viscoelastic properties for drug delivery applications.

Main Methods:

  • Utilized host-guest complexes exhibiting pH-dependent kinetic locking.
  • Incorporated these complexes as dynamic crosslinks in polymer networks.
  • Investigated mechanical, viscoelastic, and cargo release properties.

Main Results:

  • Demonstrated pH-responsive molecular interactions via kinetic locking.
  • Developed polymer networks with highly pH-tunable mechanical and viscoelastic characteristics.
  • Achieved pH-dependent cargo release from the engineered materials.

Conclusions:

  • pH-responsive host-guest complexes can create dynamic polymer networks.
  • These materials offer a self-responsive platform for targeted drug delivery.
  • The developed system enables autonomous drug release based on local pH stimuli.