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Updated: Jan 18, 2026

A Rat Carotid Artery Pressure-Controlled Segmental Balloon Injury with Periadventitial Therapeutic Application
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Integrin αvβ3 Antagonist Ameliorates Atherosclerotic Progression by Reducing Platelet Hyperactivation

Mengyun Xu1, Xurui Zhang1, Feng Qi1

  • 1Department of Cardiology, Fuwai Yunnan Hospital, Chinese Academy of Medical Sciences, Affiliated Cardiovascular Hospital of Kunming Medical University, Kunming, China.

International Journal of Toxicology
|September 8, 2025
PubMed
Summary

Platelet hyperactivation in atherosclerosis is linked to increased integrin αvβ3 and Multimerin 1 (MMRN1). Targeting this axis reduced platelet activity and disease severity in mice, offering a potential therapeutic strategy.

Keywords:
MMRN1aggregationatherosclerosishyperactivityplateletαvβ3

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