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Emerging threats in dermatophytosis: antimicrobial resistance in Trichophyton, with an emphasis on T. indotineae

Vanessa H T Tey1, Jiun Yit Pan1

  • 1National Skin Centre, Singapore.

Clinical and Experimental Dermatology
|September 8, 2025
PubMed

Insights

Antimicrobial-resistant Trichophyton infections, especially Trichophyton indotineae, are a growing global threat. Effective management requires molecular diagnostics and susceptibility testing, with a call for more research.

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Microbiology

Background:

  • Antimicrobial resistance in fungal infections poses a significant global health challenge.
  • Emerging strains of Trichophyton, particularly Trichophyton indotineae, demonstrate concerning resistance patterns.

Purpose of the Study:

  • To review the clinical features, resistance mechanisms, and challenges in diagnosing and treating antimicrobial-resistant Trichophyton infections.
  • To highlight the specific issues related to Trichophyton indotineae.

Main Methods:

  • A comprehensive literature review was conducted.
  • Focus was placed on studies detailing clinical manifestations, molecular resistance mechanisms, and diagnostic/therapeutic strategies.

Main Results:

  • Antimicrobial-resistant Trichophyton infections present complex clinical scenarios.
  • Molecular identification and antifungal susceptibility testing are crucial for effective treatment selection.
  • Trichophyton indotineae is a prominent species of concern.

Conclusions:

  • Effective management of these infections necessitates advanced diagnostic tools.
  • Further research is urgently needed to improve surveillance, diagnostic accuracy, and treatment options for emerging resistant fungal threats.

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