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Updated: Jan 18, 2026

Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy
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Treatments to Avoid Ranula Recurrence: A Network Meta-Analysis.

Marina Rocha Fonseca Souza1, Moisés Willian Aparecido Gonçalves2, Roberta Rayra Martins-Chaves3

  • 1Department of Clinical Dentistry, Pathology and Oral Surgery, Faculty of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
|September 8, 2025
PubMed
Summary
This summary is machine-generated.

No single treatment effectively prevents oral and plunging ranula recurrence. This systematic review found low certainty evidence, indicating no treatment is clearly superior for these common salivary gland cysts.

Keywords:
clinical trialsmeta‐analysisranularecurrencetreatments

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Area of Science:

  • Oral and Maxillofacial Surgery
  • Otolaryngology
  • Head and Neck Surgery

Background:

  • Oral and plunging ranulas are benign cystic lesions of the salivary glands.
  • Effective treatment strategies are needed to minimize recurrence rates.
  • Current treatment approaches lack a consensus on the most effective method.

Purpose of the Study:

  • To systematically review and evaluate various treatments for oral and plunging ranulas.
  • To assess the efficacy of different surgical and non-surgical interventions in preventing ranula recurrence.

Main Methods:

  • A comprehensive literature search was performed across five databases and gray literature.
  • Included studies investigated treatment approaches for oral or plunging ranulas.
  • A network meta-analysis (NMA) compared seven treatment strategies, assessing recurrence as the primary outcome.

Main Results:

  • Eighteen non-randomized studies were included (14 oral, 6 plunging ranulas).
  • No treatment demonstrated statistically significant superiority in preventing ranula recurrence.
  • The certainty of evidence was low to very low for all evaluated treatments.

Conclusions:

  • Current evidence is insufficient to recommend a single superior treatment for oral and plunging ranulas.
  • Further high-quality randomized controlled trials with longer follow-up are necessary.
  • Future research should focus on establishing evidence-based guidelines for ranula management.