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A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage
Published on: July 28, 2018
Vessel diameters of 14 basal cerebral arteries assessed in 1000 digital subtraction angiographies
Till Gumbel1, Cindy Richter2, Christian Martin3
1Department of Neurosurgery, University Hospital Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany.
Insights
Establishing normative values for intracranial vessel size is challenging due to variations in patient factors and disease effects. This study analyzed over 1000 cerebral angiographies to create a dataset for approximating normal vessel dimensions.
Area of Science:
- Neurology
- Radiology
- Medical Imaging
Background:
- Normative values for intracranial vessel size are difficult to establish.
- Factors like gender, height, weight, and cerebrovascular diseases influence vessel diameters.
- Cerebral angiography is typically reserved for severe conditions, complicating the definition of physiological values.
Purpose of the Study:
- To approximate "normal" values for intracranial vessel size.
- To create a comprehensive dataset of cerebral angiographic measurements.
- To enable the computation of intraindividual indices and train machine learning models.
Main Methods:
- Analysis of over 1000 contemporary cerebral angiographies from a single neurovascular center.
- Recording of diameters for 14 basal cerebral arteries, patient age, gender, and underlying disease.
- Utilized SPSS 29 (IBM) for data management of 1010 digital subtraction angiographies.
Main Results:
- A significant difference (p < 0.001) was found in the size of the left carotid artery between male and female patients.
- Male patients had a larger average left carotid artery size (3.23 mm) compared to female patients (3.09 mm).
- The dataset provides detailed measurements for statistical analysis and potential correlations.
Conclusions:
- The developed dataset offers a valuable resource for approximating normative intracranial vessel sizes.
- It can be used to compute intraindividual indices for specific diseases, aiding in the assessment of conditions like cerebral aneurysms.
- The dataset is suitable for training machine learning algorithms to predict neurological events such as ischemic stroke or cerebral hemorrhage.
Abstract:
Angiographic normative values for the size of intracranial vessels are difficult to obtain, since they vary with gender, height and weight. Cerebral angiography only is indicated in severe cerebrovascular diseases, which also can affect cerebral vessel diameters, impeding the definition of physiological values. To approximate "normal" values, over 1000 contemporary cerebral angiographies from a single neurovascular centre were analyzed. Diameters of 14 basal cerebral arteries, age at examination, gender and underlying disease were noted. The dataset (SPSS 29, IBM) comprises 1010 digital subtraction angiographies. For example, a significant difference (p < 0.001) in the size of the left carotid artery between male (3.23 mm, n = 361, sd = 0.49) and female (3.09 mm, n = 645, sd = 0.52) patients is found. The data can be used to compute intraindividual indices in given diseases, e.g. whether an enlarged diameter of the right media, calculated as ratio to the left media or to the ipsilateral carotid artery, is associated to cerebral aneurysms. The dataset allows for training of machine learning programs, e.g. to predict ischemic stroke or cerebral hemorrhage.
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