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High-resolution anorectal manometry profile in patients with chronic constipation versus control.
Rahul Deshmukh1, Shubham Jain1, Saurabh Bansal1
1Department of Gastroenterology, Topiwala National Medical College and Bai Yamunabai Laxmanrao Nair Charitable Hospital, Mumbai, 400 008, India.
Chronic constipation (CC) patients exhibit distinct high-resolution anorectal manometry (HRAM) profiles compared to healthy volunteers (HV). Functional defecation disorders (FDD) and rectal hyposensitivity are prevalent in CC, with type-1 recto-anal dyssynergia being the most common FDD subtype.
Area of Science:
- Gastroenterology
- Physiology
- Diagnostic Imaging
Background:
- Limited comparative studies exist on chronic constipation (CC) within our population.
- This study addresses the gap by comparing high-resolution anorectal manometry (HRAM) findings.
Purpose of the Study:
- To compare HRAM profiles between CC patients and healthy volunteers (HV).
- To compare HRAM profiles between CC patients with and without functional defecation disorders (FDD).
Main Methods:
- Retrospective comparative study of 120 CC patients and 60 HV.
- Utilized HRAM and balloon expulsion test (BET).
- Diagnosed FDD using ROME-IV criteria based on abnormal HRAM and BET.
Main Results:
- CC patients showed higher maximum anal squeeze pressure and rectal sensory volumes than HV.
- CC patients had significantly lower median anal relaxation, defecation index, and recto-anal pressure gradient.
- FDD was diagnosed in 57.5% of CC patients, characterized by higher anal residual pressure and lower recto-anal pressure gradients.
Conclusions:
- Significant differences exist in clinical and manometric profiles between CC patients and HV.
- FDD and rectal hyposensitivity are more common in CC patients.
- Type-1 recto-anal dyssynergia is the predominant FDD subtype in this cohort.
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