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New pterosins from Hypolepis punctata
Liang Shen1, Wenhao Mu1, Peixin Wang1
1College of Life Sciences, Shanghai Normal University, Shanghai, 2014018, People's Republic of China.
Abstract:
Two new (1-2) and eight known pterosins (3-10) were obtained from the aerial parts of Hypolepis punctata. One compound (11) was synthesized from compound 4. Their structures were established by spectroscopic methods and the absolute configuration was further determined by single-crystal X-ray diffraction analysis for compounds 1, 3 and 4. Notably, compound 1 showed low toxicity while significantly inhibiting lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells.

