Green Synthetic Amide-Modified Hyper-Cross-Linked Adsorption Resin for Efficiently Separating Chlorogenic Acid From...

Area of Science:

• Green Chemistry
• Materials Science
• Natural Product Chemistry

Background:

• Eucommia ulmoides Oliver leaf contains chlorogenic acid, known for antioxidant, antiviral, and anti-inflammatory properties.
• Efficient separation of chlorogenic acid from plant extracts is crucial for its therapeutic applications.
• Existing methods may lack efficiency or environmental friendliness.

Purpose of the Study:

• To develop a new, green functional hyper-crosslinked adsorption resin (HCREt-AM) for chlorogenic acid separation.
• To evaluate the resin's performance in extracting chlorogenic acid from Eucommia ulmoides leaf extract.
• To elucidate the adsorption mechanisms and kinetics involved.

Main Methods:

• A novel resin was synthesized using Friedel-Crafts reaction and grafting polymerization.
• Adsorption isotherms and kinetics were studied to understand the process.
• The resin's capacity and efficiency were tested using Eucommia ulmoides leaf extract.

Main Results:

• The HCREt-AM resin demonstrated excellent performance in separating chlorogenic acid.
• The adsorption process followed the Langmuir isotherm and pseudo-second-order kinetics.
• A dynamic saturated adsorption capacity of 88.0 mg·g⁻¹ was achieved, increasing chlorogenic acid content from 7.91% to 48.27%.

Conclusions:

• The developed hyper-crosslinked adsorption resin offers an effective and green strategy for chlorogenic acid purification.
• Adsorption is governed by pH-controlled ionization and involves π-π stacking, hydrophobic interactions, hydrogen bonding, and electrostatic interactions.
• This method significantly enhances the purity of chlorogenic acid from natural sources.