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Tea intake shows no genetic causal effect on stroke: A two-sample Mendelian randomization study based on STROBE-MR
Yang Liu1, Xinhong Zhang, Yuehui Liu
1Second Department of Neurology, Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, China.
Medicine
|September 9, 2025
Summary
This study found no causal link between drinking tea and stroke risk. Public health advice should not solely focus on tea for stroke prevention.
Area of Science:
- Epidemiology
- Genetics
- Public Health
Background:
- Observational studies show inconsistent associations between tea intake and stroke risk.
- Causality requires further investigation using robust methodologies.
Purpose of the Study:
- To determine the causal relationship between habitual tea consumption and stroke risk.
- Utilizing a two-sample Mendelian randomization approach.
Main Methods:
- Employed two-sample Mendelian randomization (MR) analysis.
- Utilized genome-wide association study (GWAS) summary statistics for tea intake and stroke.
- Selected 36 independent single-nucleotide polymorphisms (SNPs) as instrumental variables (IVs).
- Applied inverse variance weighting (IVW) as the primary analysis method, complemented by weighted median, MR-Egger, simple mode, and weighted mode.
Main Results:
- Inverse variance weighting (IVW) showed no causal effect of tea intake on stroke (OR = 0.997, 95% CI: 0.991-1.004).
- Consistent results were observed across all sensitivity analyses, including MR-Egger, weighted median, simple mode, and weighted mode.
- No significant heterogeneity or horizontal pleiotropy was detected, confirming the robustness of the findings.
Conclusions:
- Genetic evidence from this large-scale Mendelian randomization study does not support a causal link between habitual tea consumption and stroke risk.
- Public health strategies for stroke prevention should not solely rely on promoting tea intake.
