Association between triglyceride-glucose index and abnormal uterine bleeding in perimenopausal women

This study aims to elucidate the relationship between the triglyceride-glucose index (TyG) index and perimenopausal abnormal uterine bleeding (AUB) risk. A total of 306 patients diagnosed with perimenopausal AUB at our hospital between January 2022 and December 2023 were enrolled. Using a TyG index cutoff of 0.4, participants were divided into 2 groups: a high TyG index group (≥0.4, n = 153) and a low TyG index group (<0.4, n = 153).General clinical data, including body mass index, albumin, C-reactive protein, total protein, creatinine, serum triglycerides, fasting glucose, and TyG index, were compared between the groups. Statistical analyses were performed to evaluate the association between the TyG index and perimenopausal AUB. The study was approved by Civil Aviation General Hospital Ethics Committee (no. CAGH-2021-056), and informed consent was obtained from all participants. Significant differences were observed between the 2 groups in body mass index, albumin, C-reactive protein, total protein, creatinine, serum triglycerides, fasting glucose, bleeding duration, and TyG index (P < .05). A higher TyG index was associated with an increased risk of perimenopausal AUB (P < .05). Subgroup analyses revealed correlations between the TyG index and age ≥ 55 years, obesity, diabetes, tumor history, arthritis, stroke, thyroid disorders, and heart failure (P < .05). Notably, a nonlinear relationship was identified: when the TyG index was below 0.4, a higher index correlated with reduced AUB risk; conversely, a TyG index above 0.4 was linked to elevated AUB risk (P < .05). The TyG index is significantly associated with perimenopausal AUB, with higher values indicating increased risk. This index may serve as a predictive marker for assessing AUB risk in perimenopausal women, highlighting its potential clinical utility in early intervention and management strategies.