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Using a Brief Body Sway Assessment Device to Track Balance Differences across the Huntington's Disease Integrated

Japleen Kaur1, Nadeen Youhanan1, Krisha Bagga1

  • 1Department of neuroscience, UC San Diego, San Diego, California, USA.

Movement Disorders Clinical Practice
|September 9, 2025
PubMed
Summary

Balance impairment is an early sign of Huntington's disease (HD), progressing with disease stage. This study used the BTrackS Balance Plate to detect changes in total body sway (TBS) in HD patients and controls.

Keywords:
BalanceHD‐ISS staging systemHuntington's Diseasefalls

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Area of Science:

  • Neuroscience
  • Genetics
  • Biomedical Engineering

Background:

  • Huntington's disease (HD) is an inherited neurodegenerative disorder.
  • Balance impairment is a known symptom of HD, but its early stages are not well understood.

Purpose of the Study:

  • To investigate the onset and progression of balance issues in Huntington's disease.
  • To utilize the BTrackS Balance Plate to quantify balance deficits across HD stages.

Main Methods:

  • Assessed total body sway (TBS) in 123 HD patients and 33 healthy controls (HC) using the BTrackS Balance Plate.
  • Classified HD participants into stages 0/1, 2, and 3 using the Huntington's Disease Integrated Staging System (HD-ISS).
  • Employed receiver operating characteristic (ROC) curve analysis to determine optimal TBS cutoffs for distinguishing disease stages.

Main Results:

  • Significant differences in TBS were observed between HCs and HD participants (P < 0.001).
  • TBS significantly increased with HD progression: 9.56 cm (stage 0/1), 14.46 cm (stage 2), and 28.26 cm (Stage 3).
  • High discrimination was found between HCs and early-stage HD (AUC=0.709) and between stage 2 and 3 HD (AUC=0.71).

Conclusions:

  • Balance impairment is an early and progressive symptom in Huntington's disease.
  • TBS measurements can detect balance deficits even before overt motor symptoms appear.
  • The BTrackS Balance Plate is a valuable tool for tracking balance changes in HD progression.