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Long-Term Complete Remission of Metastatic Endometrial Carcinosarcoma With Radical Surgical Resection and
Kambiz Novin1, Soroush Shahrokh2, Mohadese Shahin1
1Radiation Oncology Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Objective:
To present a case of metastatic endometrial carcinosarcoma (ECS) with a long-term complete response to chemotherapy using a paclitaxel and carboplatin regimen.
Case Report:
A 47-year-old premenopausal woman was diagnosed with a large, advanced intrauterine tumor. She underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy. Pathological assessment revealed a uterine mass with mesenchymal and epithelial components consistent with ECS, while the right ovarian tumor was identified as serous papillary carcinoma. The patient experienced a prolonged postoperative recovery period lasting 3 months. Staging workup later revealed recurrence of adnexal and pulmonary lesions, indicating metastasis. The patient received 6 cycles of postoperative chemotherapy consisting of paclitaxel and carboplatin, achieving complete remission that has persisted for 3 years since the initial diagnosis.
Conclusions:
This case highlights the efficacy of postoperative chemotherapy using paclitaxel and carboplatin in the successful treatment of metastatic ECS.