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An Overview on Lipid Nanocapsules: Exploring the Role in Precision Cancer Treatment and Lymphatic Drug Distribution
Mahesha Keerikkadu1, Pragathi Devanand Bangera1, Vamshi Krishna Tippavajhala1
1Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, India.
Advanced Pharmaceutical Bulletin
|September 9, 2025
Summary
Lipid nanocapsules (LNCs) offer advanced cancer therapy by co-delivering drugs and enhancing tumor targeting. These nanocarriers improve drug efficacy and reduce side effects, paving the way for precise and patient-friendly treatments.
Area of Science:
- Nanotechnology
- Oncology
- Drug Delivery
Background:
- Lipid nanocapsules (LNCs) are promising nanocarriers for cancer therapy.
- The phase inversion temperature (PIT) process is a simple and stable method for LNC formulation.
- Surface functionalization enhances tumor specificity and reduces toxicity.
Purpose of the Study:
- To review recent advancements in LNC-based cancer therapies.
- To focus on optimizing LNC properties, targeting efficiency, and combination therapy.
- To highlight the translational advantages of LNCs in clinical applications.
Main Methods:
- Review of current literature on LNC formulation and application in cancer.
- Analysis of surface functionalization strategies for enhanced targeting.
- Examination of LNCs' role in combination therapy and overcoming drug resistance.
Main Results:
- LNCs enable co-delivery of multiple drugs for synergistic effects.
- Surface modification and nanoscale properties facilitate targeted delivery and EPR effect.
- LNCs improve drug bioavailability, reduce systemic toxicity, and enhance lymphatic uptake.
Conclusions:
- LNCs represent multifunctional platforms for accurate and effective cancer treatment.
- They offer significant translational advantages, including reduced toxicity and improved pharmacokinetics.
- LNCs are a patient-friendly delivery system with potential for site-specific treatment, especially in metastatic cancers.
