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Updated: Jan 18, 2026
Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Hyperparathyroidism Secondary to Burosumab Treatment
Minhtri K Nguyen1, Dhiresh Bandaru2, Minh-Kevin Nguyen3
1Medicine, Ronald Reagan University of California Los Angeles Medical Center, Los Angeles, USA.
Abstract:
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome of abnormal phosphorus metabolism caused by increased secretion of fibroblast growth factor 23 (FGF23) by small mesenchymal tumors. In this article, we reported a patient with chronic refractory hypophosphatemia due to TIO who is treated with burosumab, a monoclonal antibody that targets and blocks the activity of FGF23. Treatment with burosumab led to the resolution of his refractory hypophosphatemia, but this was complicated by the development of secondary hyperparathyroidism. This article reports a rare case of hyperparathyroidism induced by burosumab in a patient with TIO.
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