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Updated: Jan 18, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Hyperparathyroidism Secondary to Burosumab Treatment
Minhtri K Nguyen1, Dhiresh Bandaru2, Minh-Kevin Nguyen3
1Medicine, Ronald Reagan University of California Los Angeles Medical Center, Los Angeles, USA.
Tumor-induced osteomalacia (TIO) is a rare condition causing phosphorus imbalance. Treatment with burosumab resolved hypophosphatemia but induced secondary hyperparathyroidism in a TIO patient.
Area of Science:
- Endocrinology
- Oncology
- Metabolic Bone Disease
Background:
- Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by abnormal phosphorus metabolism.
- It results from excessive fibroblast growth factor 23 (FGF23) secretion by mesenchymal tumors.
- Patients often present with chronic refractory hypophosphatemia.
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