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Prognostic Value of Perioperative Serum Creatinine Kinase Levels for Metachronous Colorectal Liver Metastasis

  • 0Department of Surgery, Toho University School of Medicine, Tokyo, JPN.
Cureus +

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September 9, 2025

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September 9, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Serum creatine kinase (s-CK) levels may predict prognosis in colorectal liver metastasis patients. Consistently low perioperative s-CK levels indicate a higher risk of recurrence and mortality after liver resection.

Area Of Science

  • Oncology
  • Hepatobiliary Surgery
  • Biomarkers

Background

  • Decreased serum creatine kinase (s-CK) levels are noted in some cancers.
  • The prognostic role of s-CK in colorectal liver metastasis (CLM) is not well-established.
  • This study examines perioperative s-CK levels in patients with metachronous CLM.

Purpose Of The Study

  • To investigate the prognostic significance of perioperative serum creatine kinase (s-CK) levels.
  • To assess the relationship between s-CK levels and outcomes in patients undergoing liver resection for metachronous colorectal liver metastasis.

Main Methods

  • Retrospective analysis of 46 patients who underwent liver resection for CLM (2011-2023).
  • Serum creatine kinase (s-CK) levels measured preoperatively and 6 months postoperatively.
  • Patients stratified into low vs. high s-CK groups using the lower limit of normal as cutoff; recurrence-free survival (RFS) and overall survival (OS) analyzed.

Main Results

  • No significant difference in RFS or OS between preoperative low and high s-CK groups.
  • Postoperative low s-CK levels significantly correlated with poorer RFS (P=0.001), but not OS (P=0.072).
  • Consistently low perioperative s-CK levels were associated with significantly poorer RFS (P=0.002) and OS (P=0.038).

Conclusions

  • Perioperative serum creatine kinase (s-CK) levels show potential as prognostic predictors in metachronous colorectal liver metastasis.
  • Consistently low s-CK levels before and after liver resection may identify patients at high risk for recurrence and mortality.

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