Recent Progress in Peptide-Based Fluorescent Probes Biomedical Applications: A Review.

Area of Science:

• Biomedical research
• Molecular imaging
• Translational medicine

Background:

• Peptide-based fluorescent probes are valuable tools in biomedical research.
• They possess advantageous properties like small size, low toxicity, and high specificity.
• These probes are increasingly used in basic research and clinical applications.

Purpose of the Study:

• To provide a comprehensive review of recent advancements in peptide-based fluorescent probes.
• To highlight design strategies, biological targets, and functional applications.
• To discuss limitations and future directions for probe development.

Main Methods:

• Review of recent literature on peptide-based fluorescent probes.
• Emphasis on design strategies, targeting capabilities, and responsive mechanisms.
• Discussion of applications in various biomedical contexts.

Main Results:

• Integration of targeting and imaging, multimodal imaging, and activatable probes are key advances.
• Applications include tumor recognition, organelle targeting, non-cancer diagnosis, and ion detection.
• Responsive probes for reactive oxygen species (ROS) show diagnostic and therapeutic promise.

Conclusions:

• Peptide fluorescent probes are versatile tools with significant potential in diagnostics and therapeutics.
• Limitations in in vivo stability, targeting accuracy, and delivery need to be addressed.
• Future directions include smart platforms, self-reporting systems, and high-throughput screening.