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[Neurological complications associated with immune checkpoint inhibitors].

Magne Solberg Nes1, Åsmund Flobak2, Christian Vedeler3

  • 1Nevrologisk avdeling, St. Olavs hospital.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|September 9, 2025
PubMed
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Immune checkpoint inhibitors can cause frequent nervous system toxicities. This review details neurotoxic complications from these cancer treatments, emphasizing clinical vigilance for serious side effects.

Area of Science:

  • Neuro-oncology
  • Immunotherapy
  • Clinical Toxicology

Background:

  • Immune checkpoint inhibitors (ICIs) are revolutionary cancer therapies.
  • Immune-mediated adverse events are common with ICIs.
  • Neurological toxicities pose significant clinical challenges.

Purpose of the Study:

  • To review neurotoxic complications of immune checkpoint inhibitors.
  • To inform clinicians about potential neurological side effects.
  • To highlight the importance of vigilance in managing ICI therapy.

Main Methods:

  • Literature review of clinical studies and case reports.
  • Analysis of neurotoxicity incidence and presentation.
  • Synthesis of current understanding of ICI-related neurotoxicity.

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Main Results:

  • Neurotoxicity affects both central and peripheral nervous systems.
  • Common presentations include meningitis, encephalitis, and neuropathies.
  • Early recognition and management are crucial for patient outcomes.

Conclusions:

  • Immune checkpoint inhibitors can lead to diverse neurotoxicities.
  • Clinicians require heightened awareness of these potential complications.
  • Proactive monitoring and timely intervention are essential for safe ICI use.