Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cryptococcal Meningitis

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Multiplexed Imaging Reveals Immune-Metabolic Niches in Multiple Myeloma Linked to Progression and Bone Disease.

Blood cancer discovery·2026

Same author

Intensive chemotherapy for high-risk acute lymphoblastic leukemia in first remission: results from the NOPHO ALL2008 study.

Leukemia·2025

Same author

Early prediction of subsequent peg-asparaginase inactivation in acute lymphoblastic leukaemia patients-A NOPHO ALL2008 study.

British journal of haematology·2025

Same author

Impact of age and sex on survival outcomes in patients aged 1-45 years with acute lymphoblastic leukemia treated according to the stratification used in the NOPHO ALL2008 trial.

Haematologica·2025

Same author

A patient with minimal myeloma treatment who survived for 20 years.

Haematologica·2023

Same author

Impact of body mass index on outcome and treatment-related toxicity in young adults with acute lymphoblastic leukemia.

Acta oncologica (Stockholm, Sweden)·2023

Search research articles

Related Experiment Video

Updated: Jul 4, 2026

Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents

Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents

Published on: March 25, 2016

[A man in his 30s with psychosis and neutropenia].

Håkon Skjalg Selland Johnstuen¹, Ånon Meier Dalane², Petter Quist-Paulsen³

¹Fakultet for medisin og helsevitskap, NTNU.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke

|September 9, 2025

Summary

A young man with Asperger's syndrome and epilepsy was diagnosed with acute lymphoblastic leukemia (ALL) after presenting with severe neutropenia. This case highlights the importance of investigating blood count abnormalities, especially in patients with neurological and psychiatric conditions.

More Related Videos

Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay

Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay

Published on: May 12, 2023

Microbiological Rapid On-Site Evaluation for Pulmonary Infectious Diseases

Microbiological Rapid On-Site Evaluation for Pulmonary Infectious Diseases

Published on: March 1, 2024

Related Experiment Videos

Last Updated: Jul 4, 2026

Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents

Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents

Published on: March 25, 2016

Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay

Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay

Published on: May 12, 2023

Microbiological Rapid On-Site Evaluation for Pulmonary Infectious Diseases

Microbiological Rapid On-Site Evaluation for Pulmonary Infectious Diseases

Published on: March 1, 2024

Area of Science:

Hematology
Neurology
Oncology

Background:

Abnormal blood tests are frequent in healthcare settings.
Investigations for abnormal blood counts often span multiple specialties.
This case presents incidental blood count disturbances with a serious underlying cause.

Purpose of the Study:

To report a case of acute lymphoblastic leukemia (ALL) in a young man with Asperger's syndrome and epilepsy.
To emphasize the importance of investigating severe hematologic abnormalities.
To explore potential links between antiepileptic medication and leukemia development.

Main Methods:

Case report of a young male patient with Asperger's syndrome and epilepsy.
Initial presentation with seizures, distress, and abnormal blood tests (neutropenia, anemia, thrombocytopenia).
Diagnostic workup including bone marrow examination leading to ALL diagnosis.

Main Results:

The patient presented with severe neutropenia, mild anemia, and thrombocytopenia.
Initial treatment for delusions and discontinuation of olanzapine did not resolve blood count abnormalities.
Bone marrow examination confirmed acute lymphoblastic leukemia (ALL).

Conclusions:

Thorough investigation of hematologic abnormalities is crucial, even when incidental.
The case raises questions regarding the potential role of long-term antiepileptic drug use in leukemia development.
Further research is warranted to explore the relationship between antiepileptic medications and leukemia risk.