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Related Experiment Video

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Protocol for Studying Extinction of Conditioned Fear in Naturally Cycling Female Rats
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Estrous Cycle Impacts Fear Extinction and Relapse in Female Adolescent Rats.

August Gable1, Rick Richardson1, Kathryn D Baker1,2

  • 1School of Psychology, UNSW Sydney, Sydney, New South Wales, Australia.

Developmental Psychobiology
|September 9, 2025
PubMed
Summary
This summary is machine-generated.

Adolescent female rats show impaired fear extinction, especially during high estradiol phases. Estradiol may protect against fear relapse during this developmental period.

Keywords:
adolescenceestradiolextinctionfemalerenewal

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Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Endocrinology

Background:

  • Adolescent males and humans show deficits in extinguishing learned fear.
  • It is unknown if adolescent females exhibit similar fear extinction impairments.
  • The influence of the estrous cycle on fear extinction in adolescent females requires investigation.

Purpose of the Study:

  • To determine if female adolescent rats exhibit fear extinction impairments.
  • To investigate the impact of the estrous cycle on fear extinction in adolescent females.
  • To compare fear extinction and renewal between adolescent males and females.

Main Methods:

  • Fear conditioning followed by extinction training in female adolescent rats at different estrous cycle stages.
  • Assessment of extinction retention and fear renewal.
  • Comparison with age-matched male rats.

Main Results:

  • Peri-pubertal females showed fear responses comparable to males.
  • Postpubertal females extinguished in high estradiol (proestrus) showed less fear than males.
  • Males exhibited more fear renewal than females, indicating greater relapse.

Conclusions:

  • Fear extinction fluctuates with the estrous cycle in adolescent female rats.
  • Estradiol may offer protection against fear extinction impairments during adolescence.
  • Adolescent females may be protected from fear relapse compared to males.