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Periprosthetic joint infection: Time to think outside the box
Min-Cong He1,2, Augusto Ferrini2,3, Javad Parvizi2
1Third Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.
Summary
Surgical site infections (SSI), like periprosthetic joint infections (PJI), are increasingly linked to the patient's own microbiome. Targeting this endogenous microbiome offers a promising new strategy for preventing and managing these infections.
Area of Science:
- Orthopaedic Surgery
- Infectious Diseases
- Microbiome Research
Background:
- Surgical site infections (SSI), particularly periprosthetic joint infections (PJI), pose a significant clinical and economic challenge in orthopaedics.
- Historically, PJI was attributed to exogenous pathogens, but recent evidence highlights the role of the patient's endogenous microbiome.
- The rising incidence of total joint arthroplasty procedures is expected to increase PJI rates, underscoring the need for novel prevention and treatment strategies.
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