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Considerations in Pursuing Reaction Scope Generality.

Samson B Zacate1, Juliana A Dantas2, Song Lin1

  • 1Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA.

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Summary
This summary is machine-generated.

Generality in synthetic chemistry is gaining traction due to high-throughput technology and data science. This review explores modern workflows and strategies for developing methods with broad applicability.

Keywords:
Computational chemistryGeneralityHigh‐throughput screeningMachine learningSynthetic methods

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Area of Science:

  • Synthetic Chemistry
  • Chemical Data Science
  • Method Development

Background:

  • The concept of "generality" in synthetic chemistry is increasingly relevant.
  • High-throughput experimentation and data science tools are driving this trend.
  • A clear definition and standardized approach for method generality are currently lacking.

Purpose of the Study:

  • To examine emerging strategies for achieving generality in synthetic methods.
  • To provide an overview of modern workflows that expedite the pursuit of general methods.
  • To clarify the definition and importance of generality in contemporary synthetic chemistry.

Main Methods:

  • Literature review of emerging strategies for synthetic method generality.
  • Analysis of selected examples showcasing diverse scopes.
  • Examination of modern workflows in data-driven synthetic chemistry.

Main Results:

  • Identification of various strategies employed to enhance method generality.
  • Illustrative examples demonstrating the application of these strategies.
  • Overview of contemporary workflows facilitating the development of general synthetic methods.

Conclusions:

  • Generality is a key goal in modern synthetic chemistry, aided by technological advancements.
  • Standardized approaches are needed to systematically develop general methods.
  • This review offers insights into current practices and future directions for achieving broader method applicability.