Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Electrodeposition01:08

Electrodeposition

1.3K
Electrodeposition is a technique used to separate an analyte from interferents by electrochemical processes. Here, the analyte is a metal ion that can be deposited on an electrode immersed in the sample solution. The electrochemical setup consists of an anode and a cathode. When an electric current is applied to the setup, oxidation occurs at the anode. At the cathode, which consists of a large metal surface, metal ions undergo reduction and deposit onto the surface.
Electrodeposition can...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The road towards faster development of novel pharmacotherapies for persons with Parkinson's disease.

Journal of Parkinson's disease·2026
Same author

Modulating α-synuclein clearance: a comparison of high-frequency and direct current stimulation in preclinical models of Parkinson's disease.

Brain communications·2026
Same author

A systematic review exploring the safety of deep brain stimulation at MRI field strengths beyond conventional field strengths: Opening the door to new imaging tools for neuromodulation.

AJNR. American journal of neuroradiology·2026
Same author

Phase 2 Futility Trials in Alzheimer Disease and Mild Cognitive Impairment: A Cohort Analysis of the ADNI Data Set.

Neurology·2026
Same author

Deep brain stimulation in alpha-synuclein models of Parkinson's disease: Bridging the translational gap.

Journal of Parkinson's disease·2026
Same author

Georgina M. Aldridge, Matthew Weber and Lauren Walker recipients of the Parkinson Prize 2025.

Journal of Parkinson's disease·2026

Related Experiment Video

Updated: Jan 18, 2026

Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording
09:58

Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording

Published on: February 12, 2020

14.1K

Facile Deep Brain Electrode Coating with MXene for Improved Electrode Performance.

Laura Kondrataviciute1,2, Taufik A Valiante1,2,3,4,5,6,7, Luka Milosevic1,2,4,6,7

  • 1Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, M5T 0S8, Canada.

Advanced Healthcare Materials
|September 9, 2025
PubMed
Summary

Researchers developed novel titanium carbide (Ti3C2Tx) MXene-coated electrodes for improved brain signal recording. These enhanced electrodes offer stable, high-quality neural recordings and are compatible with MRI, advancing neuromodulation therapies.

Keywords:
MRIMXenedeep brain electrodein vivo electrophysiologyneuroinflammation

More Related Videos

Tools for Surface Treatment of Silicon Planar Intracortical Microelectrodes
06:39

Tools for Surface Treatment of Silicon Planar Intracortical Microelectrodes

Published on: June 8, 2022

2.8K
A Method for Systematic Electrochemical and Electrophysiological Evaluation of Neural Recording Electrodes
09:27

A Method for Systematic Electrochemical and Electrophysiological Evaluation of Neural Recording Electrodes

Published on: March 3, 2014

13.9K

Related Experiment Videos

Last Updated: Jan 18, 2026

Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording
09:58

Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording

Published on: February 12, 2020

14.1K
Tools for Surface Treatment of Silicon Planar Intracortical Microelectrodes
06:39

Tools for Surface Treatment of Silicon Planar Intracortical Microelectrodes

Published on: June 8, 2022

2.8K
A Method for Systematic Electrochemical and Electrophysiological Evaluation of Neural Recording Electrodes
09:27

A Method for Systematic Electrochemical and Electrophysiological Evaluation of Neural Recording Electrodes

Published on: March 3, 2014

13.9K

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Neuroscience

Background:

  • Accurate brain signal recording is crucial for neuromodulation therapies like deep brain stimulation (DBS).
  • Existing electrodes face challenges in stability, MRI compatibility, and cost-effectiveness.
  • Need for advanced electrodes that ensure high-fidelity recordings and patient safety.

Purpose of the Study:

  • To enhance the performance of carbon fiber electrodes for chronic neural recording using titanium carbide (Ti3C2Tx) MXene nanosheets.
  • To evaluate the electrical, mechanical, and biocompatibility properties of the modified electrodes.
  • To assess the long-term stability and recording capabilities of Ti3C2Tx-coated electrodes in vivo.

Main Methods:

  • A facile dip-coating approach was used to apply Ti3C2Tx MXene nanosheets onto commercial carbon fiber electrodes.
  • Electrode performance was characterized by measuring electrical conductivity, impedance, and charge storage capacity.
  • Ti3C2Tx-coated electrodes were implanted in the rat dorsal hippocampal CA1 region for chronic recording and biocompatibility assessment.
  • MRI compatibility was evaluated for the modified electrodes.

Main Results:

  • Ti3C2Tx-coated electrodes demonstrated improved electrical conductivity, stability, and reduced impedance compared to uncoated controls.
  • The modified electrodes exhibited enhanced charge storage and injection capacity.
  • In vivo implantation showed significantly lower impedance over 4 weeks, reduced line noise susceptibility, and detection of single-unit neuronal activity.
  • The Ti3C2Tx coating did not induce inflammation and maintained MRI compatibility.

Conclusions:

  • Dip-coating with Ti3C2Tx MXene nanosheets provides a facile and effective method to enhance carbon fiber electrodes for chronic neural recording.
  • These enhanced electrodes offer superior performance, stability, and biocompatibility for deep brain electrophysiology.
  • The developed electrodes represent a promising, cost-effective, and MRI-compatible solution for advanced neuromodulation therapies.