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Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy

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Optimizing Lutein Formulations for Targeted Ocular Drug Delivery: In Vitro and In Vivo Insights.

Dao Nguyen¹, Sampa Sarkar², Thilini Thrimawithana³

¹School of Medicine, Deakin University, Geelong 3220, Australia.

ACS Applied Materials & Interfaces

|September 9, 2025

Summary

This study developed stable lutein nanocarriers from Momordica cochinchinensis for enhanced eye health. The novel formulation improved lutein delivery, stability, and retinal cell protection against oxidative stress.

Keywords:

cubosome herbal therapy lutein nanomaterial retinal disease topical nutraceutical

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Area of Science:

Ophthalmology
Nanotechnology
Pharmacology

Background:

Lutein, a vital plant pigment, offers eye health benefits but suffers from instability and poor bioavailability.
Developing stable lutein formulations is crucial for treating retinal diseases.

Purpose of the Study:

To create stable lutein-loaded cubosome lipid nanocarriers (lutein-MO and lutein-MO-DOTAP) from Momordica cochinchinensis.
To evaluate the enhanced stability, retinal penetration, biocompatibility, and therapeutic potential of these nanocarriers.

Main Methods:

Lutein was encapsulated into neutral (lutein-MO) and cationic (lutein-MO-DOTAP) cubosome lipid nanocarriers.
In vitro studies assessed drug release, stability, retinal cell biocompatibility, and protection against oxidative stress.
In vivo studies evaluated retinal detection after intravitreal injection and topical eye drop application in mice.

Main Results:

The nanocarrier formulations demonstrated improved lutein stability and sustained release.
Cationic lutein-MO-DOTAP showed enhanced retinal cell uptake and superior protection against H2O2-induced stress.
In vivo studies confirmed lutein-MO-DOTAP presence in mouse retinas post-injection and topical application.

Conclusions:

Stable lutein-loaded cubosome nanocarriers were successfully developed, enhancing lutein's therapeutic potential for eye conditions.
The cationic formulation (lutein-MO-DOTAP) shows promise for improving lutein delivery to the retina.
This novel formulation could be a valuable therapeutic strategy for enhancing eye health and managing retinal diseases.