Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Radical Reactivity: Overview01:11

Radical Reactivity: Overview

2.6K
Radicals, the highly reactive species, gain stability by undergoing three different reactions. The first reaction involves a radical-radical coupling, in which a radical combines with another radical, forming a spin‐paired molecule. The second reaction is between a radical and a spin‐paired molecule, generating a new radical and a new spin‐paired molecule. The third reaction is radical decomposition in a unimolecular reaction, forming a new radical and a spin‐paired...
2.6K
Radical Chain-Growth Polymerization: Mechanism01:09

Radical Chain-Growth Polymerization: Mechanism

3.4K
The radical chain-growth polymerization mechanism consists of three steps: initiation, propagation, and termination of polymerization. The polymerization initiates when a free radical generated from the radical initiator adds to the unsaturated bond in the monomer. The unpaired electron of the free radical and one π electron in the unsaturated bond creates a σ bond between the free radical and the monomer. As a result, the other π electron in the unsaturated bond converts this species into...
3.4K
Radical Reactivity: Intramolecular vs Intermolecular01:33

Radical Reactivity: Intramolecular vs Intermolecular

2.1K
Radical reactions can occur either intermolecularly or intramolecularly. In an intermolecular radical reaction, a nucleophilic radical adds to an electrophilic alkene or vice versa. In such reactions, the radical and generally the alkene, which is also called the radical trap, are two different molecules. Additionally, for such intermolecular reactions to occur, the radical trap must be active, present in an excess concentration, and the radical starting material must have a weak...
2.1K
Radical Formation: Overview01:03

Radical Formation: Overview

2.6K
A bond can be broken either by heterolytic bond cleavage to form ions or homolytic bond cleavage to yield radicals. A fishhook arrow is used to represent the motion of a single electron in homolytic bond cleavage. There are two main sources from which radicals can be formed:
Radicals from spin-paired molecules:
Radicals can be obtained from spin-paired molecules either by homolysis or electron transfer. While two radicals are formed in the former, an electron is added in the...
2.6K
Radical Chain-Growth Polymerization: Chain Branching01:17

Radical Chain-Growth Polymerization: Chain Branching

2.4K
The skeletal structure of polymers synthesized via radical polymerization is always branched. For example, the polymerization of ethylene by radical polymerization results in a low-density grade of polyethylene with a heavily branched skeletal structure. Here, the radical site abstracts hydrogen from the growing chain, and the radical site shifts from the end (a primary carbon center) to anywhere within the growing chain (a secondary carbon center). Consequently, the part of the chain from the...
2.4K
Radical Chain-Growth Polymerization: Overview01:10

Radical Chain-Growth Polymerization: Overview

3.2K
Chain-growth or addition polymerization is successive addition reactions of monomers with a polymer chain. In radical chain-growth polymerization, the reaction proceeds via a free-radical intermediate. The free radical is formed from radical initiators, which spontaneously generate free radicals by homolytic fission. Organic peroxides (such as dibenzoyl peroxide, as shown in Figure 1) or azo compounds are popular radical initiators. A low concentration ratio of radical initiator to monomer is...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cycloparaphenylene-Derived Porous Organic Cylinders.

Journal of the American Chemical Society·2026
Same author

Atomic-scale mechanism of anisotropic ion migration in 2D Bi<sub>2</sub>O<sub>2</sub>Se nanodevices.

Nature communications·2026
Same author

Selective Synthesis of [2]Rotaxane Orientational Isomers With Precisely Arranged Luminogens: Toward Orientation-Dependent Emissions for Information Storage and Encryption.

Angewandte Chemie (International ed. in English)·2026
Same author

Robust Axially Chiral Scaffolds for High-Fidelity Circularly Polarized Electrochemiluminescence.

Analytical chemistry·2026
Same author

Predicting societal risk factors for respiratory co-infections: a cross-sectional study based on multi-source fever clinic data.

BMC infectious diseases·2026
Same author

π-Aggregation-free, fused perylene pentamers: synthesis, narrowband far-red to near-infrared emission, and chiroptical properties.

Chemical science·2026

Related Experiment Video

Updated: Jan 18, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.9K

Harnessing Radical-Based Dynamic Covalent Chemistry and Supramolecular Synthon for Directional Self-Assembly.

Shengzhong Li1, Xiao-Li Zhao1, Xueliang Shi1

  • 1State Key Laboratory of Petroleum Molecular & Process Engineering, Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.

Journal of the American Chemical Society
|September 9, 2025
PubMed
Summary

Researchers developed a new method for precisely assembling complex molecular structures using radical-based dynamic covalent chemistry and supramolecular synthons. This approach allows for controlled formation of diverse architectures with tunable thermal properties.

More Related Videos

Synthesis and Characterization of Supramolecular Colloids
09:26

Synthesis and Characterization of Supramolecular Colloids

Published on: April 22, 2016

10.4K
Grafting Multiwalled Carbon Nanotubes with Polystyrene to Enable Self-Assembly and Anisotropic Patchiness
11:09

Grafting Multiwalled Carbon Nanotubes with Polystyrene to Enable Self-Assembly and Anisotropic Patchiness

Published on: April 1, 2018

8.5K

Related Experiment Videos

Last Updated: Jan 18, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.9K
Synthesis and Characterization of Supramolecular Colloids
09:26

Synthesis and Characterization of Supramolecular Colloids

Published on: April 22, 2016

10.4K
Grafting Multiwalled Carbon Nanotubes with Polystyrene to Enable Self-Assembly and Anisotropic Patchiness
11:09

Grafting Multiwalled Carbon Nanotubes with Polystyrene to Enable Self-Assembly and Anisotropic Patchiness

Published on: April 1, 2018

8.5K

Area of Science:

  • Supramolecular Chemistry
  • Materials Science
  • Organic Chemistry

Background:

  • Precise control over self-assembly is crucial for designing functional molecular architectures.
  • Weak supramolecular interactions and synthons are key to directing self-assembly.
  • Dynamic covalent chemistry offers opportunities for creating responsive materials.

Purpose of the Study:

  • To report a new directional bonding approach for controlled self-assembly.
  • To integrate radical-based dynamic covalent chemistry with supramolecular synthons.
  • To construct and characterize novel supramolecular architectures with tunable properties.

Main Methods:

  • Construction of a novel linear macrocyclic synthon (S1) using radical-based dynamic covalent bonds.
  • Coupling of S1 with phenanthrene and carbazole linkers of varying angles.
  • Characterization of self-assembled superstructures (M1, M2, M3) using variable temperature spectroscopies (VT-UV-vis-NIR, VT-NMR, VT-EPR).

Main Results:

  • Precise self-assembly into triangular (M1) and mixed triangular/quadrangular (M2, M3) superstructures was achieved.
  • The synthon and superstructures exhibited reversible thermal association and dissociation behavior due to stable radical formation.
  • Complete thermal conversion of M2 and M3 was demonstrated, enabled by reversible radical-based dynamic covalent bonds.

Conclusions:

  • Integrating radical-based dynamic covalent chemistry with supramolecular synthons is a powerful strategy for constructing complex molecular architectures.
  • This approach enables precise control over self-assembly and the creation of multifunctional, stimuli-responsive materials.
  • The developed method opens new avenues for designing advanced materials with dynamic and tunable properties.