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Long-term complications in patients with bladder-prostate rhabdomyosarcoma treated with brachytherapy: a systematic
Giulia Brooks1, Filippo Ghidini2,3, Calogero Virgone4
1Department of Pediatric Surgery and Pediatric Minimally Invasive Surgery and New Technologies, San Bortolo Hospital, Viale Ferdinando Rodolfi 37, 36100, Vicenza, Italy.
Introduction:
Brachytherapy has been used for the multimodal treatment of pediatric bladder-prostate rhabdomyosarcoma in the last two decades. The aim of this systematic review is to gather the current evidence about this innovative technique with a special focus on long-term outcomes.
Methods:
According to PRISMA criteria, PubMed, Scopus, and Web of Science were searched for papers published between 2000 and 2022.
Results:
The search yielded 7338 papers but only seven were eligible, for a total of 196 children with a median age ranging from 23 to 32 months and a median follow-up ranging from eight to 64 months. The five-year overall survival was superior to 90%. However, at least one complication involving the urogenital apparatus was reported in 66 children (35%).
Conclusion:
Brachytherapy presented positive outcomes in terms of overall survival. On the other hand, further efforts should be made to decrease the risk of functional urogenital side effects.
