Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

184
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
184
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

167
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
167
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

165
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
165

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

(Ca/Zn)CO<sub>3</sub> Microparticles Loaded with BacitracinAntibacterial and Osteogenic Dual Action Carriers.

ACS omega·2026
Same author

Correction: Rapidly decellularized adipose tissue induces soft tissue vascularization in potential anatomical spaces.

BMC biotechnology·2025
Same author

Beta-cyclodextrin decorated hyaluronic acid-coated SPIONs for improved delivery of temozolomide.

International journal of pharmaceutics·2025
Same author

Modification of Thermo-Chemical Properties of Hot-Pressed ZrB<sub>2</sub>-HfB<sub>2</sub> Composites by Incorporation of Carbides (SiC, B<sub>4</sub>C, and WC) or Silicides (MoSi<sub>2</sub> and CrSi<sub>2</sub>) Additives.

Materials (Basel, Switzerland)·2025
Same author

The Influence of Starting Plant Material on Ni@C-Type Composites' Characteristics.

Materials (Basel, Switzerland)·2025
Same author

Interactions between Lipopolysaccharide and Peptide Bacteriocin BacSp222 Influence Their Biological Activities.

ACS infectious diseases·2025

Related Experiment Video

Updated: May 5, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

10.2K

Multifunctional Hydrogel Flakes: An Innovative Approach to Localized Delivery of Temozolomide.

Aleksandra Krajcer1,2, Alicja Hinz3, Monika Bzowska3

  • 1Doctoral School of Exact and Natural Sciences, Jagiellonian University, Prof. St. Łojasiewicza 11, Kraków 30-348, Poland.

ACS Applied Materials & Interfaces
|September 9, 2025
PubMed
Summary

This study presents novel hydrogel flakes for glioma treatment, combining temozolomide (TMZ) and vancomycin (VANC) for sustained drug delivery, antimicrobial action, and hemostasis during surgery, minimizing side effects.

Keywords:
glioblastomahemostatic propertieshydrogelslocal therapytemozolomidevancomycin

More Related Videos

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release
08:39

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

9.4K
A Rapid Screening Workflow to Identify Potential Combination Therapy for GBM using Patient-Derived Glioma Stem Cells
05:29

A Rapid Screening Workflow to Identify Potential Combination Therapy for GBM using Patient-Derived Glioma Stem Cells

Published on: March 28, 2021

3.2K

Related Experiment Videos

Last Updated: May 5, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

10.2K
Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release
08:39

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

9.4K
A Rapid Screening Workflow to Identify Potential Combination Therapy for GBM using Patient-Derived Glioma Stem Cells
05:29

A Rapid Screening Workflow to Identify Potential Combination Therapy for GBM using Patient-Derived Glioma Stem Cells

Published on: March 28, 2021

3.2K

Area of Science:

  • Biomaterials Science
  • Neuro-oncology
  • Drug Delivery Systems

Background:

  • Glioblastoma (GBM) treatment faces challenges with local recurrence, neuroinfections, and surgical bleeding.
  • Current therapies often involve systemic drug administration, leading to side effects and suboptimal dosing at the tumor site.

Purpose of the Study:

  • To develop a multifunctional hydrogel system for localized treatment of glioma.
  • To address challenges in drug delivery, infection control, and hemostasis in neurosurgery.

Main Methods:

  • Fabrication of hydrogel flakes incorporating temozolomide (TMZ) and vancomycin (VANC) within cyclodextrin/polymeric capsules.
  • Embedding capsules into a gelatin/hyaluronic acid/chitosan hydrogel cross-linked with genipin and incorporating calcium cations.
  • Utilizing freeze-drying to create flake-like forms for surgical site application and evaluating physicochemical, biological, and antimicrobial properties.

Main Results:

  • The hydrogel flakes demonstrated sustained release of TMZ and vancomycin (VANC).
  • The system exhibited significant antimicrobial activity against relevant pathogens.
  • The incorporated calcium cations provided effective hemostatic properties.
  • In vitro/ex vivo evaluations confirmed the system's biological compatibility and functionality.

Conclusions:

  • The developed multifunctional hydrogel flakes offer a promising localized drug delivery strategy for glioma treatment.
  • This system effectively combines sustained drug release, antimicrobial action, and hemostasis, addressing key challenges in neurosurgery.
  • The localized administration minimizes systemic side effects, paving the way for potential clinical applications.