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Updated: Jan 18, 2026

Pre-clinical Orthotopic Murine Model of Human Prostate Cancer
Published on: August 29, 2016
Drug Targets in Prostate Cancer: An Appetite for KLK2-Mediated Destruction
Steven Blinka1,2, Evan Y Yu1,2
1Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, Washington.
Human kallikrein 2 (KLK2), a prostate cancer protein, is now recognized as a cell surface target. This finding opens new therapeutic avenues for targeting prostate cancer through cell surface-based strategies.
Area of Science:
- Oncology
- Biochemistry
- Molecular Biology
Background:
- Human kallikrein (KLK) 2 is a protein specific to prostate cancer.
- KLK2 is regulated by androgen receptor signaling pathways.
- Previously, KLK2 was considered a secreted enzyme, not a cell surface target.
Purpose of the Study:
- To investigate the cellular localization of KLK2.
- To determine if KLK2 is a viable therapeutic target for prostate cancer.
Main Methods:
- Cell surface expression analysis of KLK2.
- Investigating KLK2 targetability using various methodologies.
Main Results:
- KLK2 is expressed on the cell surface.
- KLK2 is targetable through novel therapeutic strategies.
Conclusions:
- KLK2's cell surface expression redefines it as a potential therapeutic target.
- This discovery offers new avenues for prostate cancer treatment development.
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