Investigating the optimal reactive balance training intensity in people with chronic stroke: Study protocol for a...

Stroke significantly contributes to long-term disability, one of the problems is with impaired balance control, increasing the risk of falls. The risk of falls may be mitigated using reactive balance training (RBT) which has been shown to effectively reduce fall risk by enhancing reactive stepping following repeated balance perturbations. However, the optimal RBT intensity for people with chronic stroke remains unknown. The purpose of this assessor-blinded randomized controlled trial is to investigate the optimal intensity of RBT by comparing high-intensity, moderate-intensity, and walking control groups among 63 individuals with chronic stroke. Participants will undergo four consecutive days of training, with outcomes assessed pre- and post-training and at a one-year follow-up. The primary outcomes are reactive stepping ability, measured using number of steps required to recover balance from a novel perturbation. Secondary outcomes include rates of adverse events, functional balance, falls efficacy, and participation in daily activities. We hypothesize that high-intensity RBT will yield faster adaptations and greater retention compared to moderate-intensity and walking. Determining the optimal RBT intensity could substantially enhance clinical guidelines for stroke rehabilitation, optimize therapy efficiency, and improve patient outcomes by reducing fall risk and improving functional independence. ClinicalTrials.gov ID: NCT06555016.