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Updated: Jan 18, 2026

Co-immunoprecipitation of the Mouse Mx1 Protein with the Influenza A Virus Nucleoprotein
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Co-immunoprecipitation of the Mouse Mx1 Protein with the Influenza A Virus Nucleoprotein

Published on: April 21, 2015

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Matrix protein 1 (M1) of influenza A virus: structural and functional insights

Yanting Zhu1, Yixue Sun2, Xiaoyu Deng3

  • 1State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, and College of Veterinary Medicine, Jilin University, Changchun, People's Republic of China.

Emerging Microbes & Infections
|September 9, 2025
PubMed

Insights

Influenza A virus (IAV) matrix protein 1 (M1) is crucial for viral structure and replication. Understanding M1

Area of Science:

  • Virology
  • Structural Biology
  • Molecular Biology

Background:

  • Enveloped viruses depend on matrix proteins for structural integrity and lifecycle progression.
  • Matrix protein 1 (M1) is the most abundant structural protein in influenza A virus (IAV).

Purpose of the Study:

  • To elucidate the intricate structure and function of IAV M1 protein.
  • To highlight M1's regulatory influence on viral replication, adaptation, and morphogenesis.
  • To provide insights into viral replication dynamics and epidemiological shifts.

Main Methods:

  • Literature review of existing studies on IAV M1 protein.
  • Analysis of M1 protein's interactions with viral components and host cells.
  • Examination of M1's role in viral morphogenesis, transmissibility, and pathogenicity.

Main Results:

  • M1 protein plays multifaceted roles in viral uncoating, polymerase activity, vRNA transcription/replication, and assembly/budding.
  • M1 protein interacts with host cells and regulates viral morphogenesis.
  • M1 influences viral transmissibility and pathogenicity.

Conclusions:

  • The M1 protein is a critical determinant of IAV replication, adaptation, and pathogenesis.
  • M1's multifaceted roles and influence on viral transmissibility make it a highly attractive antiviral target.
Keywords:
Influenza A virusantiviral targetmatrix ptotein 1structureviral lifecycle

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