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Updated: Jan 18, 2026

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
Published on: May 10, 2018
[Effectiveness of GLP-1 receptor agonists in managing patients with type 2 diabetes]
Ferran Bejarano Romero1, Vicente Aragó Molés2, Daniel Morón Porrúa2
1Gerencia Atención Primaria y a la Comunidad Camp de Tarragona, Tarragona, España; Grup de Recerca Emergent en Intervencions Sanitàries i Activitats Comunitàries-GRE ISAC (2021 SGR 00884). IDIAP Jordi Gol i Gurina, Barcelona, España; Grup de recerca en Qualitat i Seguretat dels Pacients de Tarragona (2022 6G22/035). IDIAP Jordi Gol i Gurina, Barcelona, España.
Objective:
To evaluate the effectiveness of GLP-1 receptor agonists (GLP-1 RAs) in patients with type 2 diabetes mellitus and to describe their clinical characteristics.
Design:
Retrospective cohort study based on electronic health records. SITE: Health centres of the Primary and Community Care Management (GAPiC) Camp de Tarragona.
Participants:
Patients aged ≥18 years with a diagnosis of type 2 diabetes mellitus on treatment with an GLP-1 RA.
Main Measurements:
Demographic variables, glycosylated haemoglobin (HbA1c) and weight/BMI were collected to assess effectiveness; and clinical variables were recorded to assess safety.
Results:
A total of 1227 patients (50.2% male) were included. A mean average HbA1c% reduction of 0.50% in HbA1c (p<0.001), weight reduction of 3.08kg weight (p<0.001) and BMI reduction of 0.99kg/m2 (p<0,001) were observed after 472 days of average treatment.
Conclusions:
GLP-1 RAs are effective in glycemic control and weight reduction in clinical practice. The results are consistent with international studies, although somewhat lower than pivotal trials.
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