SIRT2 and NAD+ Boosting Broadly Suppress Aging-Associated Inflammation
Marine Barthez1, Zehan Song1,2, Yufan Feng1
1Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California, USA.
Aging Cell
|September 9, 2025
Summary
Aging causes chronic inflammation and tissue decline. Boosting NAD+ levels, potentially by targeting SIRT2, can reduce this inflammation and improve tissue function in older individuals.
Area of Science:
- Immunology
- Gerontology
- Biochemistry
Background:
- Aging is characterized by chronic inflammation, termed
- inflammaging,
- which contributes to age-related diseases.
- Multiple immune pathways are activated during aging, complicating therapeutic interventions.
- Sirtuin 2 (SIRT2), an NAD+-dependent deacetylase, plays a role in regulating immune responses.
Purpose of the Study:
- To investigate the role of SIRT2 in aging-associated inflammation.
- To evaluate the potential of NAD+ boosting as a strategy to counteract aging-related inflammation and tissue dysfunction.
Main Methods:
- Studied the effects of SIRT2 deficiency on inflammation and tissue function in aged models.
- Administered an NAD+ boosting compound (78c) to aged models.
- Assessed multiple immune pathways and tissue function markers.
Main Results:
- SIRT2 deficiency exacerbated inflammation and led to tissue function decline in aged individuals.
- NAD+ boosting with 78c effectively suppressed aging-associated inflammation.
- NAD+ boosting improved tissue function in aged individuals.
Conclusions:
- SIRT2 acts as a key regulator of aging-associated inflammation.
- NAD+ boosting is a promising therapeutic strategy to mitigate age-related inflammation and preserve tissue function.
More Related Videos
06:56Near Infrared NIr Light Increases Expression of a Marker of Mitochondrial Function in the Mouse Vestibular Sensory Epithelium
Published on: March 14, 2015
10.4K
10:39A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
Published on: September 17, 2020
6.7K
Related Concept Videos
01:26Aging
613
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
613
01:19The Effect of Aging on Tissues
3.4K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.4K
01:37Mitochondria
19.6K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
19.6K
01:28Inflammatory Response
16.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
16.0K
01:38Inflammation
61.7K
Overview
61.7K
02:26NF-κB-dependent Signaling Pathway
9.8K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
9.8K