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The interplay between organized lymphoid structures and thermogenic adipose tissue.
Francisco M Acosta1, Johanna Örling1, Marko Salmi2
1Turku PET Centre, University of Turku, Turku, Finland; Turku PET Centre, Turku University Hospital, Turku, Finland; InFLAMES Research Flagship Centre, University of Turku, Turku, Finland; MediCity Research Laboratories, University of Turku, Turku, Finland.
Trends in Endocrinology and Metabolism: TEM
|September 9, 2025
Summary
This review highlights the crucial link between lymphoid tissues and thermogenic adipose tissue (TAT) development and function. Organized lymphoid structures significantly influence brown and beige fat, opening new research avenues in immunometabolism.
Area of Science:
- Immunometabolism
- Adipose tissue biology
- Lymphoid tissue interactions
Background:
- Immune cells are vital for thermogenic adipose tissue (TAT) development and function.
- The role of organized lymphoid structures (lymph nodes, lymphatic vessels) in TAT remains under-explored.
Purpose of the Study:
- To review existing evidence on the connection between lymphoid tissues and TAT.
- To summarize findings on how organized lymphoid tissues impact TAT biogenesis and function.
Main Methods:
- Literature review of in vitro and in vivo studies.
- Synthesis of current knowledge on lymphoid-adipose tissue crosstalk.
Main Results:
- A significant link between lymphoid tissues and adipose tissue is evident.
- Organized lymphoid structures play a key role in TAT development and function.
Conclusions:
- Organized lymphoid tissues are important regulators of thermogenic adipose tissue.
- Further research is needed to address unsolved questions in this emerging field.
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