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Biomedical and Clinical Sciences
Oncology and Carcinogenesis
Predictive and prognostic markers
Aggregating premalignancy

Aggregating premalignancy

Daniela Senft ¹

Daniela Senft ¹

¹Nature Reviews Cancer, . nrc@nature.com.

⁰Nature Reviews Cancer, . nrc@nature.com.

Nature Reviews. Cancer +

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September 9, 2025

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September 9, 2025

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Summary

No abstract available on PubMed

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Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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