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Related Experiment Video

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An Experimental Paradigm for Measuring the Effects of Ageing on Sentence Processing
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The X-Age Project to construct a Chinese aging clock.

Jiaming Li1,2, Mengmeng Jiang1,3, Qiaoran Wang1,2

  • 1Aging Biomarker Consortium (ABC), Beijing, China.

Nature Aging
|September 9, 2025
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Summary
This summary is machine-generated.

The X-Age Project aims to develop aging clocks for the Chinese population to assess biological age and identify aging biomarkers. This initiative will aid in understanding aging and evaluating interventions for the growing elderly demographic.

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Area of Science:

  • Gerontology
  • Biomarker Discovery
  • Population Health

Background:

  • Global population is aging rapidly, particularly in China, increasing the burden of age-related diseases on healthcare systems.
  • The Aging Biomarker Consortium (ABC) initiated the X-Age Project to address the unique challenges of aging in the Chinese population.
  • Understanding biological age is crucial for managing age-related health issues and developing targeted interventions.

Purpose of the Study:

  • To develop a comprehensive aging evaluation system for the Chinese population.
  • To identify robust biomarkers of aging and construct composite aging clocks.
  • To capture and analyze biological age across diverse Chinese cohorts.

Main Methods:

  • Recruitment of diverse Chinese cohorts.
  • Standardized collection of biological samples.
  • Multimodal data acquisition including omics and clinical data.
  • Development of machine learning-based aging clock models.

Main Results:

  • The project aims to identify key aging biomarkers.
  • Development of validated composite aging clocks tailored to the Chinese population.
  • Establishment of a platform for assessing biological age and its heterogeneity.

Conclusions:

  • The X-Age Project will provide a scalable platform for understanding aging in China.
  • It will facilitate early detection of accelerated aging and evaluation of interventions.
  • This research is vital for adapting healthcare strategies to an aging population.