Toxicology of tetraethylene glycol Di-N-heptanoate

Tetraethylene Glycol-Di-N-Heptanoate (TEGDH), a chemical added to polymers to improve flexibility, has a very low acute toxicity following both oral administration and inhalation in rats. The oral LD50 is 25 g/kg in females and greater than 25 g/kg in males. Its approximate lethal concentration for a 4-hr. inhalation exposure is 14.2 mg/L with no mortalities occurring at 13.7 mg/L. The chemical produces mild to moderate irritation on rabbit skin, is not an eye irritant in the rabbit, and is not a sensitizer in the guinea pig. Repeated exposures by the oral route (28 consecutive doses of 1 g/kg) or by inhalation (6 hr/day, 5 days/week for 4 weeks at 1 mg/L) failed to produce any significant adverse response in rats. The material appears to have very low toxicity both when given orally or by inhalation and when the treatment is either acute (single dose) or subchronic (4 weeks).