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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
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Advances on the Synthesis, Reactivity, and Biological Properties of 4H-Thiochromen-4-(thio)one Derivatives
Clementina M M Santos1, Artur M S Silva2
1Centro de Investigação de Montanha (CIMO), LA SusTEC Instituto Politécnico de Bragança Campus de Santa Apolónia, Bragança, 5300-253, Portugal.
Abstract:
The aim of the present review is to provide a systematic survey on the recent advancements in the chemical synthesis of thiochromones, thiochromanones, the less explored thiochromene-4-thiones and some analogs. These compounds are used as versatile building blocks in the synthesis of other complex and polycyclic heterocyclic analogs. Highlights on biological and photophysical properties of these thio derivatives are also included and discussed. It covers the literature from 2014 to 2024, in more than 170 publications.
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