Advancement in Boron-Embedded Amino Acids: Enhancing Boron Neutron Capture Therapy for Improved Cancer Treatment...

One of the most difficult issues facing humanity today is the treatment of cancer. A binary cancer treatment called boron neutron capture therapy (BNCT) works especially well for high-grade gliomas and metastatic brain malignancies. Due to their preferential absorption by developing tumor cells, boronated amino acids have drawn a lot of attention among the several boron-containing compounds utilized as BNCT agents. In the first section of this review, the fundamental ideas of BNCT are briefly presented. In the remaining sections, we present a thorough analysis and synthesis of several boronated amino acids using distinct techniques. This article summarizes the therapeutic prospects of boron delivery agents and offers a critical analysis of them from the perspectives of nuclear medicine doctors and medicinal chemists.