Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

5.4K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
5.4K
Cell Motility through Blebbing01:16

Cell Motility through Blebbing

2.4K
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
2.4K
Adaptability of Cytoskeletal Filaments01:12

Adaptability of Cytoskeletal Filaments

5.7K
The cytoskeleton is a complex dynamic structure performing varied functions based on cellular requirements. The adaptability of the individual filaments in the cytoskeleton determines their ability to perform various functions within the cell. It can undergo rapid reorganization during processes like cell division or remain stable for several hours as in the interphase. The adaptability of these filaments depends on stringent regulatory mechanisms. The microfilament and microtubules of the...
5.7K
The Contractile Ring02:15

The Contractile Ring

7.2K
Contractile rings are composed of microfilaments and are responsible for separating the daughter cells during cytokinesis. Contractile ring assembly proceeds along with other cell cycle events; however, very few mechanistic details are known about the timing and coordination of the contractile rings with the cell cycle.
A small GTPase, RhoA, controls the function and assembly of the contractile ring. RhoA belongs to the Ras superfamily of proteins. The activation of formins by RhoA promotes...
7.2K
The Role of Actin and Myosin in Non-muscle Cells01:10

The Role of Actin and Myosin in Non-muscle Cells

4.6K
Actin and myosin or actomyosin filaments also play a significant role in cells other than those involved in muscle contraction (which occurs within the sarcomere of muscle cells). The mechanism of non-muscle cell contractile bundles was first observed in Dictyostelium and Acanthamoeba. In non-muscle cells, two bundles are commonly found: stress fibers and actomyosin adherence belts. These contractile bundles are smaller and less organized than the ones found in muscle cells. They  are held...
4.6K
Actin Polymerization and Cell Motility01:13

Actin Polymerization and Cell Motility

6.5K
Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
6.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Divergent evolutionary strategies pre-empt tissue collision in gastrulation.

Nature·2025
Same author

Differential regulation of the proteome and phosphoproteome along the dorso-ventral axis of the early <i>Drosophila</i> embryo.

eLife·2024
Same author

Autonomous epithelial folding induced by an intracellular mechano-polarity feedback loop.

PLoS computational biology·2021
See all related articles

Related Experiment Video

Updated: Jan 18, 2026

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo
08:19

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo

Published on: October 17, 2011

13.3K

Integrating Tissue and Cytoplasmic Rigidity Transitions During Morphogenesis.

Sameer Thukral1, Bipasha Dey1, Yu-Chiun Wang1

  • 1Laboratory for Epithelial Morphogenesis, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.

Development, Growth & Differentiation
|September 10, 2025
PubMed
Summary
This summary is machine-generated.

Material properties are key to morphogenesis, influencing both tissue and cell mechanics. This review integrates multi-scale rigidity transitions, linking cellular and tissue levels for a unified understanding of organism development.

Keywords:
cross‐scale feedbackcytoplasmic organizationmacromolecular crowdingrigidity transitiontissue jamming

More Related Videos

Fixation of Embryonic Mouse Tissue for Cytoneme Analysis
08:46

Fixation of Embryonic Mouse Tissue for Cytoneme Analysis

Published on: June 16, 2022

2.9K
Imaging Cell Shape Change in Living Drosophila Embryos
11:20

Imaging Cell Shape Change in Living Drosophila Embryos

Published on: March 30, 2011

14.7K

Related Experiment Videos

Last Updated: Jan 18, 2026

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo
08:19

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo

Published on: October 17, 2011

13.3K
Fixation of Embryonic Mouse Tissue for Cytoneme Analysis
08:46

Fixation of Embryonic Mouse Tissue for Cytoneme Analysis

Published on: June 16, 2022

2.9K
Imaging Cell Shape Change in Living Drosophila Embryos
11:20

Imaging Cell Shape Change in Living Drosophila Embryos

Published on: March 30, 2011

14.7K

Area of Science:

  • Biophysics
  • Developmental Biology
  • Cell Biology

Background:

  • Morphogenesis relies on mechanical forces and chemical signals to guide cell and tissue dynamics.
  • Material properties are crucial at both tissue and cytoplasmic scales, governing deformation and molecular interactions.
  • Rigidity transitions, observed in tissues (fluid-like to solid-like) and cytoplasm (crowdedness/diffusivity), are vital for morphogenesis.

Purpose of the Study:

  • To review mechanisms controlling rigidity transitions at tissue and cytoplasmic scales.
  • To propose an integrated, multi-scale perspective linking these transitions.
  • To explore feedback mechanisms connecting cellular and tissue-level material properties.

Main Methods:

  • Literature review of studies on rigidity transitions at different length scales.
  • Analysis of how cellular processes influence tissue-scale material properties.
  • Exploration of potential feedback loops between cytoplasmic and tissue-level mechanics.

Main Results:

  • Rigidity transitions at tissue and cytoplasmic scales are critical but often studied in isolation.
  • Tissue properties are influenced by cellular and cytoplasmic processes like adhesion, tension, and signaling.
  • Integrated multi-scale analysis reveals potential cross-scale feedback mechanisms.

Conclusions:

  • Bridging the conceptual gap between cytoplasmic and tissue-scale rigidity transitions is essential for understanding morphogenesis.
  • New biological mechanisms governing morphogenesis may emerge from this integrated perspective.
  • Understanding these multi-scale transitions offers insights beyond physical principles of inert systems.