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Development and characterization of a prototype selenium-75 high dose rate brachytherapy source.

Jonathan Kalinowski^1,2, Oren Tal², Jake Reid^1,2

¹Medical Physics Unit, Department of Oncology, Faculty of Medicine, McGill University, Montréal, Québec, Canada.

Medical Physics

|September 10, 2025

Summary

This summary is machine-generated.

The novel SeCure source design using Selenium-75 shows promise as a high dose rate brachytherapy source. Its dosimetric and spectral properties are suitable for clinical applications, paving the way for manufacturing.

Keywords:

Monte Carlo brachytherapy dosimetry selenium‐75

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Published on: March 11, 2021

Area of Science:

Medical Physics
Nuclear Engineering
Materials Science

Background:

Selenium-75 (Se-75) offers advantages over Iridium-192 (Ir-192) for high dose rate brachytherapy due to its longer half-life and lower average gamma energy.
Despite Se-75's benefits, a Se-75 brachytherapy source has not yet been manufactured.

Purpose of the Study:

To evaluate the feasibility of a novel Se-75 based source design (SeCure) for dosimetry and manufacturability.
To develop an activated prototype SeCure source for brachytherapy applications.

Main Methods:

Monte Carlo simulations were used to model the SeCure source and calculate its TG-43U1 dosimetry parameters, photon spectrum, and shielding properties (HVL1, TVL1) in lead, tungsten, and concrete.
A prototype source with a vanadium diselenide core was manufactured and its composition verified using neutron radiography.
The prototype source was activated to a nominal activity of 8.5 ± 0.9 mCi, with activity measured by dose calibrators and contaminants analyzed via gamma spectroscopy and wipe testing.

Main Results:

The SeCure source requires 2.056 ± 0.003 times the activity of Se-75 compared to Ir-192 for equivalent dose rates.
The mean spectral energy of the SeCure source is 214.695 ± 0.005 keV, leading to reduced shielding requirements.
The activated prototype achieved the target activity, and contamination levels were below 0.1%, confirming encapsulation integrity.

Conclusions:

The SeCure source design demonstrates suitable dosimetric, spectral, and physical properties for a feasible high dose rate brachytherapy source.
Further development will focus on manufacturing a high-activity SeCure source for clinical use.