Spike-timing-dependent plasticity offers delay-gated oscillatory potentiation for autaptic weights
Risa Onda1, Mihoko Ishida1, Kouhei Hattori1
1Faculty of Science and Engineering, Waseda University, Shinjuku, Tokyo, Japan.
Frontiers in Neural Circuits
|September 10, 2025
Summary
Spike-timing-dependent plasticity (STDP) in neurons with autapses causes synaptic weights to oscillate. This modulation, influenced by delay and frequency, may promote neural network synchronization.
Area of Science:
- Neuroscience
- Computational Neuroscience
- Computational Biology
Background:
- Neuronal networks perform filter functions via synaptic weights.
- Synaptic weights are autonomously regulated without external supervision.
- Autapses, or recurrent feedback connections to the same neuron, are present in animal brains.
Purpose of the Study:
- To computationally investigate how spike-timing-dependent plasticity (STDP) adjusts synaptic weights.
- To explore the role of autapses in synaptic weight modulation.
- To understand the impact of autaptic delay and stimulation frequency on synaptic plasticity.
Main Methods:
- Utilized a single Hodgkin-Huxley-type neuron model with autapses.
- Employed computational simulations to analyze synaptic weight dynamics.
- Investigated the effects of varying autaptic delay and high-frequency stimulation.
Main Results:
- Synaptic weights exhibited oscillatory potentiation and depression.
- The observed oscillations were dependent on autaptic delay and stimulation frequency.
- STDP-mediated weight modulation was confirmed in the presence of autapses.
Conclusions:
- STDP-mediated autaptic weight modulation is influenced by autaptic delay and input frequency.
- This mechanism may contribute to network-level synchronization in neural systems containing neurons with autapses.
- Autapses play a significant role in regulating synaptic plasticity and network dynamics.
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