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Updated: Jan 18, 2026
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Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
Published on: August 18, 2020
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Association Between Cannabis Use and Neuropsychiatric Disorders: A Two-sample Mendelian Randomization Study
Wei Guo1, Lin Dong2, Qingxing Lu2
1Jilin Provincial Center for Disease Control and Prevention, 130062 Changchun, Jilin, China.
Alpha Psychiatry
|September 10, 2025
Summary
Cannabis use may increase the risk of developing Parkinson's disease and attention-deficit/hyperactivity disorder (ADHD) in women. Further research is needed to understand these causal links and potential adverse effects.
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- Cannabis use is increasing, with potential applications in neuropsychiatric disorders.
- Epidemiological studies suggest cannabis affects neurocognition, but causal links to disorders remain unclear.
- This study investigates the causal relationship between genetically predicted cannabis use and neuropsychiatric disorders.
Purpose of the Study:
- To determine if genetically predicted lifetime cannabis use causally influences the risk of common neuropsychiatric disorders.
- To analyze the association between cannabis use and specific conditions like Parkinson's disease and ADHD.
Main Methods:
- Utilized a two-sample Mendelian randomization approach.
- Employed genome-wide association study (GWAS) summary statistics for cannabis use and 10 neuropsychiatric disorders.
- The inverse variance weighted (IVW) method was the primary analytical model.
Main Results:
- Lifetime cannabis use was associated with an increased risk of Parkinson's disease (OR = 1.782, p = 0.038).
- A significant association was found with increased ADHD risk in female participants (OR = 1.650, p = 0.029).
Conclusions:
- Cannabis intake may be causally linked to adverse neuropsychiatric outcomes.
- Clinical attention to cannabis side effects is crucial to prevent potential brain and neurocognitive harm.
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