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Are Sex-Specific Cutoffs Needed With a Next-Generation Urine Tenofovir Lateral Flow Assay for Antiretroviral
Xin Niu1,2, Derin Sevenler3,4, Sandy Dossantos3
1Department of Epidemiology, University of Washington, Seattle, Washington, USA.
Open Forum Infectious Diseases
|September 10, 2025
Abstract:
Accurate point-of-care tools are needed to detect early nonadherence to daily HIV regimens and support timely transitions to long-acting options. Emerging evidence suggests that females may require higher adherence than males to achieve equivalent protection. Our next-generation urine tenofovir assay showed high accuracy across sexes but lower urine drug levels among female participants.
