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Updated: Jan 18, 2026

Measuring Local Anaphylaxis in Mice
Published on: October 14, 2014
True Anaphylaxis Due to an Amide-Type Local Agent: A Case Report
Hikaru Matsumoto1, Akira Nemoto1, Yukitoshi Niiyama1
1Department of Anesthesiology and Intensive Care Medicine, Akita University Graduate School of Medicine, Akita, JPN.
Abstract:
Local anesthetics (LAs) are widely used to relieve surgical pain. Pure amide-type LAs rarely cause allergic reactions. Here, we present a case of anaphylaxis induced by multiple pure amide agents. We report a case of a 17-year-old girl with no history of allergies who was scheduled to undergo orthopedic surgery. She presented with anaphylactic symptoms after receiving peripheral nerve blocks. Postoperative allergy tests were positive for two kinds of amide-type LAs: pure lidocaine and ropivacaine. In conclusion, cross-reactivity should be considered in case of an allergic reaction to an amide-type agent.
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