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Skull-meninges-brain connectivity and extra-axial brain tumours
Abdurrahman I Islim1,2, Alexandros Vyziotis1, Omar N Pathmanaban1,3
1Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance NHS Foundation Trust, University of Manchester, Manchester M6 8FJ, UK.
Brain Communications
|September 10, 2025
Summary
The brain
Area of Science:
- Neuroscience
- Immunology
- Anatomy
Background:
- The brain's meninges (dura, arachnoid, pia mater) are crucial for immune regulation.
- The meningeal lymphatic network connects the brain, immune system, and skull bone marrow.
- Immune cells in the meninges influence brain health and disease.
Purpose of the Study:
- To review meningeal structure and function.
- To explore the link between meningeal immunity and brain tumors.
- To understand meningeal roles in headaches and anxiety.
Main Methods:
- Literature review of meningeal structure, function, and immunity.
- Analysis of immune cell interactions within the meninges.
- Examination of meningeal involvement in brain tumor microenvironments.
Main Results:
- Meningeal lymphatic vessels regulate immune responses in health and disease.
- Immune cells aggregate in meningeal hubs near cranial nerves and sinuses.
- Extra-axial brain tumors like meningioma and vestibular schwannoma interact with meningeal immunity.
Conclusions:
- Meningeal immunity plays a significant role in brain tumor progression.
- Bidirectional interactions between tumors and meninges may influence inflammation and symptoms.
- Further research into meningeal-tumor interactions is warranted.
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