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Sequential changes in body composition during infection: electron probe study IV.

B L Nichols, G L Bilbrey, C F Hazlewood

    The American Journal of Clinical Nutrition
    |September 1, 1977
    PubMed
    Summary
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    Muscle electrolyte and water composition change during infection. Studies in monkeys revealed two patterns of muscle response, involving sodium-potassium exchange or cellular fluid and sodium increase, impacting potassium levels.

    Area of Science:

    • Biochemistry
    • Physiology
    • Infectious Disease

    Background:

    • Infection significantly alters human muscle electrolyte and water balance.
    • Two primary mechanisms of muscle response to infection have been proposed.
    • These involve shifts in sodium (Na), potassium (K), and water content.

    Purpose of the Study:

    • To investigate the specific mechanisms of muscle electrolyte and water alterations during infection.
    • To analyze the patterns of muscle response using an experimental model.

    Main Methods:

    • Induction of Salmonella typhimurium sepsis in a monkey model.
    • Utilizing electron probe microanalysis to assess muscle composition.
    • Analyzing serum osmoles to understand cellular solute changes.

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    Main Results:

    • Observed two distinct patterns of muscle response to sepsis.
    • Demonstrated that potassium (K) loss is linked to intracellular saline accumulation, diluting K concentration.
    • Identified increased undetermined serum osmoles, suggesting a role for intracellular organic osmoles.

    Conclusions:

    • Sepsis induces complex electrolyte and water shifts in muscle tissue.
    • Intracellular fluid accumulation is a key factor in potassium dilution during infection.
    • Further research is needed to elucidate the role of organic osmoles in these cellular changes.