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Epicardial Adipose Tissue and Liver Fibrosis in Patients With Type 2 Diabetes Mellitus and Metabolic
Simona Cernea1,2, Andrada Larisa Roiban3,4, Danusia Onișor5,6
1Department M3/Internal Medicine I, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureş, 540142 Târgu Mureş, Romania.
Background:
Epicardial adipose tissue (EAT) is an indicator of high cardiovascular and metabolic risk. This study aimed to investigate the association between EAT thickness (EATT) and liver fibrosis and steatosis in patients with type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated steatotic liver disease (MASLD).
Methods:
Patients with T2DM and MASLD underwent a complex evaluation, which included clinical, laboratory, and liver and transthoracic cardiac ultrasound assessments. The EATT was measured using the standard method. Liver fibrosis and steatosis were evaluated by several non-invasive indexes, through which patients with severe steatosis and advanced fibrosis were identified. Correlations between the EATT and markers of liver fibrosis and steatosis were evaluated by bivariate and multiple regression analyses.
Results:
In this study population of 267 T2DM patients with MASLD, the median EATT value was 7 mm. 43.8% of study patients had an EATT >7 mm. The EATT was higher in patients with advanced liver fibrosis (8.97 ± 2.88 mm vs. 7.09 ± 2.38 mm; p < 0.0001) and in those with more severe hepatic steatosis (7.69 ± 2.70 mm vs. 6.61 ± 1.88 mm; p = 0.0310). A higher percentage of patients with advanced liver fibrosis had an EATT of >7 mm (68.3% vs. 36.7%; odds ratio (OR) = 3.72 [95% confidence interval (CI): 2.02; 6.87]; p < 0.0001). In the bivariate analyses, the EATT significantly correlated with the markers of body adiposity, non-invasive indexes of liver steatosis and fibrosis, aspartate aminotransferase (ASAT), gamma glutamyl transpeptidase (GGT), diabetes duration, and pO2. The multiple regression analyses indicated that the EATT was independently associated with fibrosis-4 (FIB-4) score and body fat mass, and with serum ferritin (in fully adjusted models), while the correlation with the markers of hepatic steatosis became non-significant after adjustments for body adiposity.
Conclusion:
T2DM patients with MASLD and markers of advanced liver fibrosis have higher EATT, which was independently associated with liver fibrosis.
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