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18F FDG PET/CT in a Rare Case of Erdheim-Chester Disease with Extensive Cutaneous and Skeletal Involvement
Anjali Prakash1, Shagos Gopalan Santhamma1, C Ashwini1
1Department of Nuclear Medicine and Molecular Imaging, Aster Medcity, Kochi, Kerala, India.
Insights
Erdheim-Chester disease (ECD), a rare histiocytosis, presents diagnostic challenges due to varied symptoms. This case highlights FDG PET/CT
Area of Science:
- Oncology
- Radiology
- Pathology
Background:
- Erdheim-Chester disease (ECD) is a rare systemic non-Langerhans cell histiocytosis.
- ECD involves multiple organs and presents with variable clinical manifestations, making diagnosis difficult.
- 18F-2-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is crucial for ECD assessment.
Purpose of the Study:
- To present a rare case of Erdheim-Chester disease.
- To illustrate the utility of FDG PET/CT in identifying extensive cutaneous lesions in ECD.
Main Methods:
- Case report of a patient diagnosed with Erdheim-Chester disease.
- Utilized 18F-2-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for imaging.
Main Results:
- FDG PET/CT revealed extensive cutaneous lesions in addition to typical skeletal involvement.
- The imaging findings underscore the comprehensive organ involvement possible in ECD.
Conclusions:
- FDG PET/CT is a valuable tool for diagnosing and staging Erdheim-Chester disease.
- This case emphasizes the importance of considering FDG PET/CT for detecting diverse ECD manifestations, including cutaneous lesions.
Abstract:
Erdheim-Chester disease (ECD) is a rare systemic non-Langerhans cell histiocytosis with multiple organ involvement. Being a rare disease with variable clinical manifestations, it is often difficult to diagnose. 18F-2-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) plays a vital role in assessing disease extent and severity, diagnosis, treatment response and is a potential biomarker for BRAF mutation. We present here a rare case of ECD with FDG PET/CT showing extensive cutaneous lesions apart from skeletal involvement.
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